Healthspan Evidence Profiles

SGLT2 inhibitors (empagliflozin, dapagliflozin) are the highest-evidence longevity compound class in the registry, with A+ grades for both…

Semaglutide is the highest-evidence longevity compound in the ClinEvident registry. Originally approved for type 2 diabetes (Ozempic) and…

Metformin has extensive observational evidence suggesting longevity benefits, including the landmark UKPDS study showing reduced all-cause…

Urolithin A is the cleanest evidence story in the supplement space. Timeline/Amazentis has published six human clinical trials showing…

CoQ10 has the longest clinical evidence history of any longevity supplement. A 2024 meta-analysis found CoQ10 supplementation significantly…

Rapamycin has the strongest preclinical lifespan extension data of any compound — consistent results across yeast, worms, flies, and…

Spermidine is an autophagy inducer with an interesting epidemiological signal — the Bruneck Study (n=829, 20-year follow-up) found that…

NR (Tru Niagen by ChromaDex) shares the NAD+ precursor mechanism with NMN but has a slightly stronger evidence base. ChromaDex has…

NMN is among the most popular longevity supplements, but its evidence grade is D+ — reflecting a significant gap between consumer…

D+Q is the original senolytic combination, pioneered by James Kirkland at Mayo Clinic. The concept — selectively killing senescent cells…

Fisetin exemplifies the senolytic evidence gap. A 2018 preclinical study identified it as the most potent senolytic flavonoid, extending…

Quercetin as a standalone supplement has weak evidence for longevity. Its primary interest is as the 'Q' in D+Q senolytic therapy, but…