Metabolic Rx (Repurposed) Cardiovascular Neurological Hepatic Musculoskeletal

Metformin

met-FOR-min USAN

Formula C4H11N5 MW 129.16 g/mol PubChem CID 4091 →

IUPAC 3-(diaminomethylidene)-1,1-dimethylguanidine

SMILES CN(C)C(=N)N=C(N)N

2D structure

Evidence Grade Strength of published clinical evidence — not a safety rating or a recommendation. How to read this

Dimension Scores

Human Outcome

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Biomarker Relevance

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Signal Source Quality

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Organ Specificity

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Interaction Certainty

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Translational Maturity

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Per-dimension evidence strength is part of the full analysis Unlock full analysis

No indication-level signals recorded yet. The grade above has not been decomposed, so it should be read as a whole-compound assessment rather than a claim about any one indication.

Evidence Summary

Metformin has extensive observational evidence suggesting longevity benefits, including the landmark UKPDS study showing reduced all-cause mortality in diabetic patients. A 2024 Nature study showed 4-6 year DNA methylation age rescue in primates.

However, the TAME trial (Targeting Aging with Metformin) — designed to establish aging as a treatable indication — remains incompletely funded as of 2026. Without TAME results, metformin's longevity evidence stays observational.

Critical interaction: The MASTERS RCT confirmed that metformin blunts exercise-induced muscle adaptations via AMPK pathway competition. This is built into our interaction database as a documented antagonistic interaction.

Safety Considerations

GI side effects (diarrhea, nausea) common at initiation. Vitamin B12 depletion with long-term use — monitor levels. Lactic acidosis risk (very rare, primarily in renal impairment). MASTERS trial confirmed blunting of exercise adaptations — timing separation recommended. Contraindicated in eGFR <30.

Evidence Signals (0)

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Known Interactions (1)

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Products Containing Metformin

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1 commercial product is listed for this molecule. Create a free account to see them, with each product's dose next to the evidence dose.

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Regulatory Intelligence

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This evidence profile reflects publicly available research as of March 15, 2026. Evidence grades may change as new research is published. ClinEvident grades the quality of published evidence — it does not evaluate the efficacy of any specific commercial product.