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A
Deeper = more human clinical evidence. The line drops from the surface; where it stops is the depth reached.
D+
Dashed bronze line: trials were run and missed their primary endpoint — a finding, not a gap.
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Exercise

B
Longevity Behavioral CardiovascularMusculoskeletalNeurological

Exercise carries a stronger human outcome base than any graded supplement in this registry — decades of randomized trials and large cohorts with hard endpoints including all-cause…

Grade and summary pending review
Reviewed 2026-10-22

Diet — Mediterranean pattern

B-
Longevity Behavioral CardiovascularMetabolicNeurological

The Mediterranean dietary pattern has hard-endpoint randomized evidence (PREDIMED) for cardiovascular event reduction — unusual among dietary interventions, which are dominated by…

Grade and summary pending review
Reviewed 2026-10-22

Sleep

C+
Longevity Behavioral

Sleep duration and quality are among the most consistently associated exposures in observational aging research, across very large cohorts. The gap is interventional: trials that…

Grade and summary pending review
Reviewed 2026-10-22

Fasting / Time-Restricted Eating

C+
Longevity Behavioral

Time-restricted eating changes when you eat rather than what. Randomised trials show modest metabolic changes, but most run for weeks rather than years, and several find the benefit tracks…

Grade and summary pending review
Reviewed 2026-10-22

Meditation

C-
Longevity Behavioral

Trials report modest changes in blood pressure and stress markers over weeks to months. Blinding is impossible and active-control design is inconsistent, so it is frequently unclear whether…

Grade and summary pending review
Reviewed 2026-10-22

EFT / tapping (Emotional Freedom Techniques)

D
Longevity Behavioral

Human randomised trials exist, which is why this is graded rather than screened out. Reported cortisol reductions are real, but a 2020 replication decoupled the marker from the outcome:…

Grade and summary pending review
Reviewed 2026-10-22