Longevity / Aging Supplement cardiovascular brain immune

Spermidine

SPUR-mi-deen
Formula C7H19N3 MW 145.25 g/mol PubChem CID 1102 →

IUPAC N-(3-aminopropyl)butane-1,4-diamine

SMILES C(CCNCCCN)CN
2D structure
C- 42.0/100

Evidence Summary

Spermidine is an autophagy inducer with an interesting epidemiological signal — the Bruneck Study (n=829, 20-year follow-up) found that higher dietary spermidine intake was associated with reduced all-cause mortality. This is real observational data from a well-conducted cohort study.

However, supplemental spermidine trials are small and use biomarker endpoints. The gap between dietary association and supplemental efficacy is significant. The C- grade reflects genuine but preliminary evidence.

Safety Considerations

Generally well-tolerated. Naturally present in foods (wheat germ, aged cheese, mushrooms). Limited safety data for high-dose supplementation.

Evidence Signals (0)

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Products Containing Spermidine

No commercial products are currently listed for this molecule.

Regulatory Intelligence

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This evidence profile reflects publicly available research as of March 15, 2026. Evidence grades may change as new research is published. ClinEvident grades the quality of published evidence — it does not evaluate the efficacy of any specific commercial product.