Musculoskeletal Supplement musculoskeletal cardiovascular immune

Urolithin A (Mitopure)

yoor-oh-LITH-in A
Formula C13H8O4 MW 228.2 g/mol PubChem CID 5488186 →

IUPAC 3,8-dihydroxybenzo[c]chromen-6-one

SMILES C1=CC2=C(C=C1O)C(=O)OC3=CC(=CC=C32)O
2D structure
C+ 53.5/100

Evidence Summary

Urolithin A is the cleanest evidence story in the supplement space. Timeline/Amazentis has published six human clinical trials showing improved mitochondrial function and muscle endurance. It holds GRAS status, Informed Sport certification, and has the strongest regulatory profile of any longevity supplement.

However, the trials are relatively small (40-100 participants), short-term (4-6 months), and use surrogate biomarkers rather than hard clinical endpoints. No mortality or major morbidity data exists. The C+ grade reflects real but preliminary evidence.

Safety Considerations

Generally well-tolerated. GRAS status. No significant adverse events in published trials. Pregnant/nursing should avoid due to insufficient data.

Evidence Signals (0)

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Products Containing Urolithin A (Mitopure)

These are commercial products that contain this molecule. The grade above applies to the molecule as tested in published trials — it is not a grade of any product below. We show each product's actual dose next to the evidence dose so you can see the match or the gap.

Mitopure Timeline
500 mg
urolithin Aper 2 softgels/dayOtc
Cellular Energy Complex Generic Stack
100 mg
urolithin Aper capsuleOtc
Proprietary blend — molecule amount not disclosedContains other actives (not graded here): CoQ10, PQQ, B-vitamin blend

Product information retrieved 5/28/2026. Formulations change without notice — verify on the label before use.

Regulatory Intelligence

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This evidence profile reflects publicly available research as of March 15, 2026. Evidence grades may change as new research is published. ClinEvident grades the quality of published evidence — it does not evaluate the efficacy of any specific commercial product.