Interaction Checker
Check documented combinations across graded compounds and behaviors. The picker tells you whether a pair has evidence on record before you run the check — including when it does not.
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Results
Metformin + Exercise
Antagonistic
Competition at AMPK. Metformin activates AMPK pharmacologically; exercise activates it through energy stress. The MASTERS randomized trial found attenuated gains in aerobic capacity and muscle adaptation in the metformin arm versus placebo, both undergoing the same training programme.
Source: MASTERS randomized trial
Other combinations with evidence on record
- Semaglutide + ExerciseSynergisticKey pairing
- Fisetin + Quercetin (standalone)Additive
- NMN (Nicotinamide Mononucleotide) + NR (Nicotinamide Riboside / Tru Niagen)Additive
- Berberine + ExerciseConditional
- Semaglutide + Rapamycin (Sirolimus)Unclear
- Metformin + ExerciseAntagonistic
- Metformin + Rapamycin (Sirolimus)Additive